BACE1相关论文
由β-淀粉样蛋白（Aβ）的异常聚集形成的Aβ寡聚体和最终形成的淀粉样斑块（俗称老年斑）是阿尔茨海默病（AD）发病过程中显著的病理学标志之......
淀粉样蛋白（β-amyloid, Aβ）沉淀是阿尔茨海默症（Alzheimer disease,AD）的重要病理特征之一。Aβ是由淀粉样前体蛋白（amyloid precurso......
阿尔茨海默氏病（Alzheimer’s disease,AD）是一种以渐进性记忆力丧失和认知障碍为主要症状的神经退行性疾病,在患者脑部出现两个明显......
学位
目的 观察补肾活血法对快速衰老SAMP8小鼠学习记忆能力以及脑内β淀粉样蛋白(Aβ)和淀粉样品体裂解酶(BACE1)的影响,探究补肾活血......
目的 探讨4种开窍药对APP/PS1双转基因小鼠的药效学及对Aβ/BACE1的影响.方法 将80只APP/PS1双转基因小鼠随机分为8组,雌雄各半,每......
我国已步入老龄化社会,脑卒中发病率不断增加。2012年数据显示脑卒中发病率以每年8.7%速度上升。研究指出64%脑卒中患者伴有不同程......
目的 探究CysLT1 R对APP-HEK293细胞中Aβ生成的影响并探寻其可能的作用机制.方法 构建慢病毒载体LV-CysLT1 R-EGFP并转染APP-HEK2......
Physalin B(PB),one of the major active steroidal constituents of Solanaceae Physalis plants,has a wide variety of bio-lo......
Alzheimers disease (AD) is the most common neurodegenerative disease,and the pathogenesis of AD is complex.Amyloid beta ......
Downregulating IGF-1R alleviates β-amyloid deposition in cortex induced by chronic sleep restriction
Aim In chronic sleep restriction(CSR)mice model,we have showed the Aβ accumulation in frontal cortex in adult wildtype(......
目的：血管性认知障碍(vascular cognitive impairment,VCI)是由脑血管危险因素、明显或不明显的脑血管病引起的从轻度认知障碍到痴......
The aspartyl protease BACE1 as β-site the amyloid precursor protein (APP)-cleaving enzyme is involved in myelination.Th......
Chronic brain hypoperfusion(CBH)is considered as a preclinical condition of mild cognitive impairment and is thought to ......
Physalin B reduce secretion of Aβ by inhibiting phosphorylation ofSTAT3 via down-regulated expressio
OBJECTIVE Extracellular amyloid-β(Aβ)plaques are one of the major pathological hallmarks of Alzheim-er disease(AD).The......
MicroRNA-195 protects against dementia induced by chronic brain hypoperfusionvia its anti-amyloidoge
OBJECTIVE To evaluate the effect of microRNA on memory impairment of chronic brain hypoperfusion (CBH)rats generated by ......
Background: Aging is associated with the gradual cognitive decline and shows the typical senile plaque formation in the ......
Alzheimers disease (AD) is a pathology characterized by the presence of too much amyloid-beta (Ap) in the brain and the ......
PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of ty
OBJECTIVE Pioglitazone, known as a peroxisome proliferator-activated receptor γ (PPARγ) agonist, is used to treat type......
β-淀粉样蛋白(amyloid-beta,Aβ)在中枢神经系统内的聚集与阿尔兹海默症(Alzheimersdisease,AD)的发生、发展密切相关[1,2].Aβ是......
会议
目的探讨银杏叶片联合奥拉西坦在非痴呆性血管认知障碍(VCIND)患者中应用效果与安全性。方法选取我院VCIND患者102例,随机数字表法......
The β‐secretase,β‐site amyloid precursor protein(APP)cleaving enzyme 1(BACE1),is the first of two proteases(the ......
目的:研究拉莫三嗪促使BACE1降解的机制,为阿尔茨海默症的临床治疗提供新的理论支持。方法:利用三个月大的APP/PS1小鼠,通过连续喂......
Beta-site amyloid precursor protein(APP)cleaving enzyme-1(BACE1):brief overview on the biology and its role in Alzheimer......
β-分泌酶(BACE1)是水解淀粉样前体蛋白生成β-淀粉样多肽的关键限速酶,近年来已成为治疗阿尔茨海默症的一个理想靶点。本文以34个......
目的 探讨microRNA-9 (miR-9) 靶向BACE1参与Alzheimer病 (AD) 发生发展的机制.方法选取2013年5月-2015年5月解放军第161医院收治......
The Effect of Dendrobium Nobile Lindl.Alkaloids on the Protein Expression of Aβ42,APP and BACE1 of H
Objective:Beta-amyloid(Aβ)deposition is considered as vital factor leading to cognitive impairment in Alzheimers diseas......
阿尔兹海默症(Alzheimer’s Disease,AD)是痴呆症的主要类型之一,也是21世纪的重大健康挑战之一。阿尔兹海默症是一种神经退行性疾......
随着世界上各地患有AD（Alzheimer’s disease,AD）的人数字的持续增长,它们带来的经济和社会问题变得越来越严重。淀粉样蛋白（Amyloid......
阿尔茨海默症（Alzheimer’s disease AD）是老龄化社会的重要疾病,并成为威胁老年人群健康的四大杀手之一。淀粉样蛋白Aβ在大脑中不......
目的:1.评估慢性氯胺酮给药大鼠受电针治疗前后的学习记忆能力是否有改善。2.观察并比较慢性氯胺酮给药大鼠受电针治疗前后海马及......
研究目的:探讨孤儿核受体NR4A1过表达对APP代谢和Tau磷酸化的影响,并阐述其可能机制。研究方法:18月龄APP/PS1和WT小鼠麻醉后处死......
目的:探讨没食子儿茶素没食子酸酯(EGCG)对含有APP_(695)突变的SH-SY5Y神经细胞中淀粉样肽(amyloid-β,Aβ)生成的影响及其机制。......
本文通过对已有小分子库进行虚拟筛选, 得到了可与BACE1活性中心Asp228、Asp32形成氢键作用的苯甲脒片段, 并在其基础上, 设计出了......
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黄连为著名的清热泻火中药,体外活性筛选发现,黄连甲醇提取物能够通过抑制Aβ42聚集、乙酰胆碱酯酶(AChE)和β分泌酶(BACE1)的活性......
